Aluminium lithium hydride → HCID 59187380, compound

Participants

Reaction Steps

To a solution of 6-cyclopropyl-5-methoxypyridine-2-carbonitrile (3-5, 115 mg, 0.66 mmol, 1 equiv) in THF (2.6 mL) at 0° C. was added LAH (1 M, 1.98 mL, 1.98 mmol, 3 equiv) slowly. The reaction mixture was stirred and allowed to warm to ambient temperature over 3 hours. The reaction mixture was then diluted with EtOAc (2 mL), and water (50 uL), NaOH (aq., 20 wt. %, 50 uL) and water (100 uL) were added sequentially. The reaction mixture was then dried over MgSO4, filtered and concentrated to afford the product (3-6). ESI+MS [M+H]+ C10H15N2O: 179.1 found, 179.2 required.

Provenance & Evidence