Sodium bis(trimethylsilyl)amide → HCID 178467403, compound

Participants

Reaction Steps

To a solution of 3-(2-amino-5-bromophenyl)-2-ethoxy-N,N-diisopropylisonicotinamide (17.9 g, 43 mmol) in THF (213 mL) at 0° C. was added sodium bis(trimethylsilyl) amide (1.0 M in THF, 85 mL, 85 mmol). The solution was stirred for 2 hr and monitored by LCMS. Another 10 mL of sodium bis(trimethylsilyl) amide was added and stirred for an additional 30 min. The solution was quenched with methanol and concentrated to a slurry which was subsequently triturated with water and filtered to provide the title compound.

Provenance & Evidence