Thionyl Chloride → 9h-Fluoren-9-ylmethyl[5-(chlorosulfonyl)-2,4-dimethylphenyl]carbamate

Participants

Reaction Steps

To a solution of 5-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-2,4-dimethylbenzenesulfonic acid (5 g, 11.8 mmol) in DMF (5.9 mL) was added thionyl chloride (4.3 mL, 59.0 mmol). The reaction was stirred at room temperature for three hours and then quenched by the addition of water. The colorless precipitate was then collected by filtration and dried in vacuo to afford 9H-fluoren-9-ylmethyl[5-(chlorosulfonyl)-2,4-dimethylphenyl]carbamate as a colorless solid.

Provenance & Evidence