Hydrochloric Acid → HCID 59436026, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 9-bromo-N-[2,6-dichloro-4-(2-methyl-1,3-dioxolan-2-yl)phenyl]-1-methoxybenzo[c]-2,6-naphthyridin-5-amine (1.40 g, 2.62 mmol) in THF (24 mL) was added 6 N HCl (8mL) and the reaction mixture was heated to 85° C. for 45 min. The solution was cooled to room temperature and neutralized with sat. NaHCO3. The mixture was extracted with a mixture of 1:3 iPrOH/CHCl3. The organic layers were combined, dried over MgSO4, filtered, and concentrated to afford the title compound.

Provenance & Evidence