Boron tribromide → HCID 59436013, compound

Participants

Reaction Conditions

Reaction Steps

A solution of N-{2,6-dichloro-4-[(trifluoromethyl)thio]phenyl}-10-methoxypyrido[4,3-c]-1,6-naphthyridin-6-amine (15 mg, 0.03 mmol), N-{2,6-dichloro-4-[(trifluoromethyl)thio]phenyl}-10-ethoxypyrido[4,3-c]-1,6-naphthyridin-6-amine (15 mg, 0.03 mmol) and boron tribromide (0.256 ml, 0.26 mmol) in chloroform (10 ml) was stirred in a microwave vial. The vial was sealed and heated to 85° C. for 45 minutes. The crude reaction mixture was washed with sodium bicarbonate and extracted with 3:1 chloroform:isopropanol. Combined organics were concentrated under reduced pressure to afford the title compound.

Provenance & Evidence