Aniline, 2,6-dichloro-4-iodo- → HCID 59436068, compound

HRID 1802499Notes

Reaction equation

HRID 1802499 reaction equation
Cl[C:2]1[C:11]2[CH:12]=[CH:13][N:14]=[C:15]([O:16]CC)[C:10]=2[C:9]2[C:4](=[CH:5][CH:6]=[N:7][CH:8]=2)[N:3]=1.ClC1C2C=CN=C(Cl)C=2C2C(=CC=NC=2)N=1.[Cl:35][C:36]1[CH:42]=[C:41]([I:43])[CH:40]=[C:39]([Cl:44])[C:37]=1[NH2:38]>>[Cl:35][C:36]1[CH:42]=[C:41]([I:43])[CH:40]=[C:39]([Cl:44])[C:37]=1[NH:38][C:2]1[C:11]2[CH:12]=[CH:13][NH:14][C:15](=[O:16])[C:10]=2[C:9]2[C:4](=[CH:5][CH:6]=[N:7][CH:8]=2)[N:3]=1

Participants

4

Reactant 3

HCID 12770Aniline, 2,6-dichloro-4-iodo-HCID 59436091HCID 59436091, compoundHCID 59436097HCID 59436097, compound

Product 1

HCID 59436068HCID 59436068, compound

Procedure

The title compound was synthesized following the procedure in Example 155, Steps 1, 2, and 3 using 6-chloro-10-ethoxypyrido[4,3-c]-1,6-naphthyridine (Example 133, Step 3), 6,10-dichloropyrido[4,3-c]-1,6-naphthyridine (124 mg, 0.495 mmol) (Example 133, Step 3), and 2,6-dichloro-4-iodoaniline as the starting materials.

Sources & evidence

ORD record
ord-30e19316838941d294b3ce45b9a3650f
Source dataset
uspto-grants-2013_01
Patent number
US08349865B2

Reaction notes

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