Morpholine → HCID 59436088, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 9-bromo-5((2,6-dichloro-4-fluorophenyl){[2-(trimethylsilyl)ethoxy]methyl}amino)-2-{[2-(trimethylsilyl)ethoxy]methyl}benzo[c]-2,6-naphthyridin-1(2H)-one (58 mg, 0.08 mmol) in dioxane (2 ml) was added morpholine (14.16 mg, 0.16 mmol), xantphos (9.41 mg, 0.02 mmol), cesium carbonate(79 mg, 0.24 mmol) and Pd2(dba)3 (7.44 mg, 8.13 μmol). The solution was degassed by bubbling nitrogen for few minutes and heated to 100° C. in a sealed tube for 16 h. After cooling to room temperature, the reaction mixture was filtered and the filtrate was evaporated under vacuum to afford the title compound.

Provenance & Evidence