HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 4-Azidomethyl 1-(4-iodophenyl)imidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Sodium Azide | HCID 33557 | — |
| Reactant | 4-Chloromethyl 1-(4-iodophenyl)imidazole | HCID 59260062 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-Azidomethyl 1-(4-iodophenyl)imidazole | HCID 59260098 | 91% |
Reaction Steps
The compound 4-chloromethyl 1-(4-iodophenyl)imidazole 1-3 (0.780 g, 2.45 mmol) was dissolved in DMF (10 mL). To the solution, NaN3 (0.520 g, 8.00 mmol) was added. After being stirred at room temperature overnight, water and EtOAc were added. The organic layer was separated, dried over Na2SO4, concentrated in vacuo to give 4-azidomethyl 1-(4-iodophenyl)imidazole 1-4 as a solid (0.725 g). MS 326.0 (M+H)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08349873B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-04e8f21394044bc9a80c77478f00ddd7 |
| Source note | uspto-grants-2013_01 |