HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Azidomethyl 1-(4-iodophenyl)imidazole → 4-Aminomethyl 1-(4-iodophenyl)imidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Azidomethyl 1-(4-iodophenyl)imidazole | HCID 59260098 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-Aminomethyl 1-(4-iodophenyl)imidazole | HCID 59260109 | 90.4% |
Reaction Steps
A solution of 4-azidomethyl 1-(4-iodophenyl)imidazole 1-4 (0.725 g, 2.23 mmol) over Ra—Ni (50% aq. slurry, 300 mg) in MeOH (12 mL) was hydrogenated under balloon H2 for 3 h. The mixture was filtrated through CELITE. The filtrate was concentrated in vacuo to give 4-aminomethyl 1-(4-iodophenyl)imidazole 1-2 as a solid (0.603 g). MS 300.0 (M+H)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08349873B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-d319003c519a4ff6b020f9b980906250 |
| Source note | uspto-grants-2013_01 |