Methyl iodide → HCID 178469908, compound

HRID 1802648Notes

Reaction equation

HRID 1802648 reaction equation
[SH:1][C:2]1[NH:3][CH:4]=[C:5]([C:7]([O:9][CH2:10][CH3:11])=[O:8])[N:6]=1.[CH3:12]I>CC(C)=O>[CH3:12][S:1][C:2]1[NH:3][CH:4]=[C:5]([C:7]([O:9][CH2:10][CH3:11])=[O:8])[N:6]=1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 178469909HCID 178469909, compound

Product 1

HCID 178469908HCID 178469908, compoundYield 80%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

To a suspension of ethyl 2-mercapto-1H-imidazole-4-carboxylate (4.00 g, 23.3 mmol) in acetone (30 mL) at room temperature, MeI (6 mL, 96.3 mmol) was added. During first 10 min of stirring, the suspension became clear, then it turned cloudy as product began to precipitate out. After being stirred at room temperature overnight, the precipitate was collected, dried on vacuum to give ethyl 2-(methylthio)-1H-imidazole-4-carboxylate (3.47 g).

Workup

  1. customto precipitate out
  2. stirringAfter being stirred at room temperature overnight
  3. customthe precipitate was collected
  4. customdried on vacuum

Sources & evidence

ORD record
ord-c069c8e9c1f340c8a98146f39b207033
Source dataset
uspto-grants-2013_01
Patent number
US08349873B2

Reaction notes

Loading…