5-chloro-7-nitro-2-phenyl-1H-indole → HCID 25214967, compound

HRID 1802815Notes

Reaction equation

HRID 1802815 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([N+:11]([O-])=O)[CH:10]=1)[NH:7][C:6]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[CH:5]2.CC1C=C2[C:27](=C([N+]([O-])=O)C=1)[NH:26][C:25]([C:33]1[CH:38]=[CH:37][CH:36]=CC=1)=C2>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([NH:11][CH:38]3[CH2:33][CH2:25][N:26]([CH3:27])[CH2:36][CH2:37]3)[CH:10]=1)[NH:7][C:6]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[CH:5]2

Participants

3

Reactant 2

HCID 684721085-chloro-7-nitro-2-phenyl-1H-indoleHCID 68477399HCID 68477399, compound

Product 1

HCID 25214967HCID 25214967, compoundYield 69%

Procedure

5-Chloro-7-nitro-2-phenyl-1H-indole (337 mg, 1.23 mmol) was reacted instead of 5-methyl-7-nitro-2-phenyl-1H-indole in Preparation 50 to give the title compound 288 mg (Yield 69%).

Sources & evidence

ORD record
ord-7846889db65545eeb366d3c4988f6d1e
Source dataset
uspto-grants-2013_01
Patent number
US08349885B2

Reaction notes

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