反应详情

Commercially available 4-chloro-2-nitro-phenylamine (17.4 g, 131.5 mmol) was dissolved in ethanol (300 mL), and thereto silver nitrate (27 g, 157.7 mmol) and iodine (40 g, 157.7 mmol) were added. The mixture was stirred for 8 hours at room temperature. At the end of reaction, the mixture was filtered using celite and washed with 100 ml of ethylacetate and concentrated. To the concentrate, added water and extracted with ethylacetate. The organic layer was washed with saturated sodium chloride solution and dried over anhydrous magnesium sulfate to give 2-amino-5-chloro-3-nitro-phenyliodide (27.4 g, Yield 69%).

1. customAt the end of reaction
2. filtrationthe mixture was filtered
3. washwashed with 100 ml of ethylacetate
4. concentrationconcentrated
5. additionTo the concentrate, added water
6. extractionextracted with ethylacetate
7. washThe organic layer was washed with saturated sodium chloride solution
8. dry with materialdried over anhydrous magnesium sulfate