Potassium Hydroxide → HCID 59437142, compound

Participants

Reaction Steps

3-Iodo-7-nitro-1H-indazole (2.50 g, 8.65 mmol) obtained in Step 1 was dissolved in acetone (50 mL), and thereto potassium hydroxide (0.73 g, 12.97 mmol) and 4-methoxybenzylchloride (1.63 g, 10.38 mmol) were added in drops at 0° C. The mixture was stirred for 2 hours. At the end of reaction, the mixture was diluted with water, and extracted with ethylacetate. The extract was washed with saturated sodium chloride solution, dried over anhydrous magnesium sulfate and filtered. The solvent was removed under reduced pressure and the residue was separated by column chromatography to give 3-iodo-7-nitro-1-(4-methoxybenzyl)-1H-indazole (3.2 g, Yield 91%).

Provenance & Evidence