HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1802840Generated: October 31, 2026
5-Fluoro-2-methoxyphenylboronic acid → 3',5-Difluoro-2-methoxy-4'-(phenylsulfonyl)biphenyl
https://huagongshe.com/reaction/1802840
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 5-Fluoro-2-methoxyphenylboronic acid | HCID 2782673 | — |
| Reactant | 4-Bromo-2-fluoro-1-(phenylsulfonyl)benzene | HCID 67374087 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Toluene | HCID 1140 | — |
| Solvent | Sodium Carbonate | HCID 10340 | — |
| Product | 3',5-Difluoro-2-methoxy-4'-(phenylsulfonyl)biphenyl | HCID 67238966 | — |
Reaction Steps
To a solution/suspension of the product from part (i) (0.55 g), 5-fluoro-2-methoxy-phenylboronic acid (0.3 g) in toluene (6 ml), ethanol (4 ml) and 2M Na2CO3 (3 ml) was added tetrakis(triphenylphosphine)palladium (0.05 g). The mixture was heated to 85° C. for 3 h, concentrated under reduced pressure to give a crude material. The residue was suspended in water, extracted with ethylacetate, washed with brine, dried (MgSO4) and concentrated under reduced pressure. Purification using flash column chromatography (eluent 10% diethylether/hexane) gave the subtitle compound, yield 0.39 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08349897B2 |
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| Source dataset | uspto-grants-2013_01 |
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| ORD ID | ord-2f273edd40e14f4ab5a35c55456bba86 |
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| Source note | uspto-grants-2013_01 |
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