反应详情

Ferric chloride (0.5 g) was added to a mixture of 4-bromo-3-fluoro-benzenesulfonyl chloride (2.5 g) and fluorobenzene (3 ml) and then stirred at reflux for 18 hours. The flask was cooled to room temperature and the residue was partitioned between aqueous NaHCO3 and DCM, The DCM layer was washed with brine, dried (MgSO4) and evaporated under reduced pressure. The residue was recrystallised from ethanol to give buff coloured crystals.

1. temperatureat reflux for 18 hours
2. customthe residue was partitioned between aqueous NaHCO3 and DCM
3. washThe DCM layer was washed with brine
4. dry with materialdried (MgSO4)
5. customevaporated under reduced pressure
6. customThe residue was recrystallised from ethanol
7. customto give buff coloured crystals