HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1802856Generated: November 1, 2026
Potassium Carbonate → Isohexane ethyl acetate
https://huagongshe.com/reaction/1802856
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | (R)-2-Tosyloxypropionic acid methyl ester | HCID 12884153 | — |
| Reactant | 3',5-Difluoro-4'-[(2-fluorophenyl)sulfonyl]biphenyl-2-ol | HCID 67241538 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | Isohexane ethyl acetate | HCID 21882781 | — |
| Product | Methyl (2s)-2-({3',5-difluoro-4'-[(2-fluorophenyl)sulfonyl]biphenyl-2-yl}oxy)propanoate | HCID 67240103 | — |
Reaction Steps
The product of step (v) (175 mg), the product of step (vi) (124 mg) and potassium carbonate (133 mg) in acetonitrile (10 ml) were charged to a flask and stirred at 65° C. overnight. The reaction mixture was cooled, diluted with water (20 ml) and extracted with diethyl ether. The combined organic extracts were washed with brine, dried (MgSO4) and concentrated under reduced pressure. The residue was purified by chromatography on silica eluting with isohexane then 4:1 isohexane/ethyl acetate to give the sub-title compound as a colourless oil, yield 121 mg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08349897B2 |
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| Source dataset | uspto-grants-2013_01 |
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| ORD ID | ord-47850f2c0cfb494cb3f4ff311e7585f0 |
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| Source note | uspto-grants-2013_01 |
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