5-Fluoro-2-methoxyphenylboronic acid → 2-Chloro-5'-fluoro-2'-methoxybiphenyl-4-yl phenyl sulfone

HRID 1802861Notes

Reaction equation

HRID 1802861 reaction equation
[C:1]1([S:7]([C:10]2[CH:15]=[CH:14][C:13](Br)=[C:12]([Cl:17])[CH:11]=2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[F:18][C:19]1[CH:20]=[CH:21][C:22]([O:28][CH3:29])=[C:23](B(O)O)[CH:24]=1>>[C:1]1([S:7]([C:10]2[CH:15]=[CH:14][C:13]([C:21]3[CH:20]=[C:19]([F:18])[CH:24]=[CH:23][C:22]=3[O:28][CH3:29])=[C:12]([Cl:17])[CH:11]=2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 27826735-Fluoro-2-methoxyphenylboronic acidHCID 216929204-Bromo-3-chlorophenyl phenyl sulfone

Product 1

HCID 672389982-Chloro-5'-fluoro-2'-methoxybiphenyl-4-yl phenyl sulfone

Procedure

The subtitle compound was prepared by the method of example 2 step (ii) using the product of step (i) and 5-fluoro-2-methoxybenzene boronic acid.

Sources & evidence

ORD record
ord-ab4479e5214d4b59a121dd70a1f89d0e
Source dataset
uspto-grants-2013_01
Patent number
US08349897B2

Reaction notes

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