(2-Methoxy-5-methylphenyl)boronic acid → 2-Fluoro-2'-methoxy-5'-methylbiphenyl-4-yl 4-fluorophenyl sulfone

HRID 1802873Notes

Reaction equation

HRID 1802873 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([S:8]([C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=2)(=[O:10])=[O:9])=[CH:4][C:3]=1[F:18].[CH3:19][C:20]1[CH:21]=[CH:22][C:23]([O:29][CH3:30])=[C:24](B(O)O)[CH:25]=1>>[F:17][C:14]1[CH:15]=[CH:16][C:11]([S:8]([C:5]2[CH:6]=[CH:7][C:2]([C:22]3[CH:21]=[C:20]([CH3:19])[CH:25]=[CH:24][C:23]=3[O:29][CH3:30])=[C:3]([F:18])[CH:4]=2)(=[O:10])=[O:9])=[CH:12][CH:13]=1

Participants

3

Reactant 2

HCID 2773485(2-Methoxy-5-methylphenyl)boronic acidHCID 684345101-Bromo-2-fluoro-4-[(4-fluorophenyl)sulfonyl]benzene

Product 1

HCID 684369542-Fluoro-2'-methoxy-5'-methylbiphenyl-4-yl 4-fluorophenyl sulfone

Procedure

The subtitle compound was prepared by the method of example 2 step (ii) using the product of example 9 step (i) and 5-methyl-2-methoxybenzene boronic acid.

Sources & evidence

ORD record
ord-eea2ce82264049b6b61462ebdeffd01a
Source dataset
uspto-grants-2013_01
Patent number
US08349897B2

Reaction notes

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