Acetic Acid → HCID 44247704, compound

Participants

Reaction Steps

A mixture of 5-[4-(cyclopropylsulfonyl)-5-methoxy-1H-indazol-1-yl]-1-[5-(1,2-dihydroxy-2-methylpropyl)pyridin-2-yl]-6-(tetrahydro-2H-pyran-4-yl)hexane-1,4-dione (0.37 g), ammonium acetate (0.23 g), acetic acid (0.34 mL) and ethanol (10 mL) was stirred at room temperature for 15 hr. To the reaction mixture was added saturated aqueous sodium hydrogen carbonate solution, and the mixture was extracted with ethyl acetate. The ethyl acetate layer was washed with saturated brine, dried (MgSO4), and concentrated. The residue was subjected to silica gel column chromatography, and eluted from hexane-ethyl acetate (1:1-0:1, volume ratio) to give the title compound (60 mg, yield 17%) as a colorless amorphous solid. MS: 595 (MH+).

Provenance & Evidence