HuagongsheHuagongshe Chemistry Print Report · For research reference only
12-Phenyllauric acid → (R)-4-dimethylamino-3-(12-phenyl-dodecanoylamino)-butyric acid benzyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 12-Phenyllauric acid | HCID 151922 | — |
| Reactant | (R)-benzyl 3-amino-4-(dimethylamino)butanoate dihydrochloride | HCID 46223507 | — |
| Product | (R)-4-dimethylamino-3-(12-phenyl-dodecanoylamino)-butyric acid benzyl ester | HCID 66875086 | — |
Reaction Steps
The title compound, m/e=403.6 ([M−H]−), was produced in analogy with intermediate 1, steps 3 and 4. Thus, commercially available 12-phenyldodecanoic acid was coupled in step 3 with (R)-3-amino-4-dimethylamino-butyric acid benzyl ester dihydrochloride to produce (R)-4-dimethylamino-3-(12-phenyl-dodecanoylamino)-butyric acid benzyl ester, which was hydrogenated in step 4.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08349893B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-27834df8312044188bf891ca108f5a31 |
| Source note | uspto-grants-2013_01 |