HCID 58282163, compound → HCID 58282131, compound

HRID 1803001Notes

Reaction equation

HRID 1803001 reaction equation
C([O:4][CH2:5][CH2:6][C:7]([O:10][C:11](=[O:24])[C:12]([O:14][C:15]([CH3:23])([CH2:17][CH2:18][O:19]C(=O)C)[CH3:16])=[O:13])([CH3:9])[CH3:8])(=O)C>C(Cl)Cl.C(NC(C)C)(C)C>[C:12]([O:14][C:15]([CH3:23])([CH2:17][CH2:18][OH:19])[CH3:16])(=[O:13])[C:11]([O:10][C:7]([CH3:9])([CH2:6][CH2:5][OH:4])[CH3:8])=[O:24]

Participants

4

Reactant 1

HCID 58282163HCID 58282163, compound

Product 1

HCID 58282131HCID 58282131, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 7912DiisopropylamineSolvent

Procedure

The cleavable diol is made in the following manner. To a solution of compound (73) in methylene chloride, diisopropylamine is added and the solution is stirred until reaction is complete. A standard aqueous workup is done and the diol should remain in the organic phase. Evaporate the solvent and collect bis(4-hydroxy-2-methylbutan-2-yl) oxalate (74).

Workup

  1. customEvaporate the solvent
  2. customcollect bis(4-hydroxy-2-methylbutan-2-yl) oxalate (74)

Sources & evidence

ORD record
ord-03ad304b235b4861a18ffe57e957eeb9
Source dataset
uspto-grants-2013_01
Patent number
US08349990B2

Reaction notes

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