2-Phenoxyethanamine → 6-Chloro-N-(2-phenoxyethyl)-2-quinolinamine

Participants

Reaction Conditions

Reaction Steps

A stirred mixture of 2,6-dichloro-quinoline (1.0 g, 5.1 mmol) and 2-phenoxyethylamine (1.5 g, 11 mmol) was heated in the microwave for 1 h at 120° C. Purification by flash chromatography on silica gel (ethyl acetate/heptane 100:0→70:30) yielded (6-chloro-quinolin-2-yl)-(2-phenoxy-ethyl)-amine as a light yellow oil (1.1 g, 73%), MS: m/e=299.3 (M+H+).

Provenance & Evidence