Methyl iodide → HCID 86649893, compound

Participants

Reaction Conditions

Reaction Steps

Step D (5): Iodomethane (0.066 mL, 1.07 mmol) was added to a solution of 1-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)thiourea (280 mg, 1.07 mmol) in absolute ethanol (5 mL). The resulting mixture was heated at 50° C. for 3 h. After cooling to rt, the reaction was concentrated in vacuo. The crude residue was purified using silica gel chromatography (0-10% MeOH/chloroform, linear gradient over 72 min, flow 25 mL/min) to afford 1-(4-isothiocyanato-2-methoxyphenyl)-4-methyl-1H-imidazole hydroiodide (135 mg, 46% yield) as a white solid. LC-MS (M+H)+ 277.2.

Provenance & Evidence