Methyl iodide → HCID 178504020, compound

Participants

Reaction Conditions

Reaction Steps

Step J (5): Iodomethane (0.047 mL, 0.753 mmol) was added to a solution of 1-(4-(4-chloro-1H-imidazol-1-yl)-3,5-difluorophenyl)thiourea (207 mg, 0.717 mmol) in absolute ethanol (4 mL). The resulting mixture was heated at 60° C. for 16 h. After cooling to rt, the reaction was concentrated in vacuo. The residual volatiles were removed in high vacuo to afford methyl 4-(4-chloro-1H-imidazol-1-yl)-3,5-difluorophenylcarbamimidothioate hydroiodide (309 mg, 0.717 mmol, 100% yield). LC-MS (M+11)+ 303.1.

Provenance & Evidence