HuagongsheHuagongshe Chemistry Print Report · For research reference only
(3,4-Difluorophenyl)acetic acid → 6-Chloro-2-(3,4-difluorophenyl)hexanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (3,4-Difluorophenyl)acetic acid | HCID 69571 | — |
| Reactant | 1-Chloro-4-iodobutane | HCID 82527 | — |
| Reactant | Sodium bis(trimethylsilyl)amide | HCID 2724254 | — |
| Product | 6-Chloro-2-(3,4-difluorophenyl)hexanoic acid | HCID 58110057 | 88% |
Reaction Steps
Step AG (1): 2-(3,4-Difluorophenyl)acetic acid (2.5 g, 14.52 mmol) was deprotonated with NaHMDS (1.0 M in THF, 29.0 mL, 29.0 mmol) and reacted with 1-chloro-4-iodobutane (1.78 mL, 14.5 mmol) using a procedure analogous to Step AC (1) to afford 6-chloro-2-(3,4-difluorophenyl)hexanoic acid (3.35 g, 88% yield). LC-MS (M−H)− 261.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08349880B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-b84876602eed46f2b6307f003d748f88 |
| Source note | uspto-grants-2013_01 |