Bromine → 6-Bromo-2-methyl-2-phenyl-cyclohexanone

HRID 1803208Notes

Reaction equation

HRID 1803208 reaction equation
[Br:1]Br.[CH3:3][C:4]1([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH2:9][CH2:8][CH2:7][CH2:6][C:5]1=[O:10]>C(Cl)(Cl)(Cl)Cl>[Br:1][CH:6]1[C:5](=[O:10])[C:4]([CH3:3])([C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH2:9][CH2:8][CH2:7]1

Participants

4

Reactant 2

HCID 24408BromineHCID 3499432-Methyl-2-phenylcyclohexanone

Product 1

HCID 581100436-Bromo-2-methyl-2-phenyl-cyclohexanone

Reagents, catalysts & solvents 1

HCID 5943Carbon TetrachlorideSolvent2×

Procedure

Step AAB (1): A solution of bromine (0.068 ml, 1.328 mmol) in CCl4 (2 mL) was added dropwise, over a period of 10 min, to a solution of 2-methyl-2-phenylcyclohexanone (250 mg, 1.328 mmol) in CCl4 (8 mL) at 0° C. The resulting solution was allowed to warm to rt and stir for 2 hr. The reaction mixture was concentrated in vacuo to afford 6-bromo-2-methyl-2-phenylcyclohexanone. The crude product was used for subsequent chemistry without purification or characterization.

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-ec5c111fc9ed49a58fa3f02f47318402
Source dataset
uspto-grants-2013_01
Patent number
US08349880B2

Reaction notes

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