Bromine → HCID 58110166, compound

HRID 1803211Notes

Reaction equation

HRID 1803211 reaction equation
[Br:1]Br.[CH2:3]([CH:10]1[CH2:15][CH2:14][CH2:13][CH2:12][C:11]1=[O:16])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1>C(Cl)(Cl)Cl>[CH2:3]([CH:10]1[CH2:15][CH2:14][CH2:13][CH:12]([Br:1])[C:11]1=[O:16])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

Participants

4

Reactant 2

HCID 24408BromineHCID 989452-Benzylcyclohexan-1-one

Product 1

HCID 58110166HCID 58110166, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Step AAD (1): Followed the method of B. Miller and H.-S. Wong Tetrahedron 1972, 28, 2369. Bromine (0.082 mL, 1.59 mmol) in was added dropwise over a period of 15 min to a solution of 2-benzylcyclohexanone (300 mg, 1.593 mmol) in chloroform (5 mL). The reaction mixture was stirred at rt for 2 h, then concentrated in vacuo to afford 2-benzyl-6-bromocyclohexanone. The crude product, which is prone to decomposition, was used for subsequent chemistry without purification or characterization.

Workup

  1. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-41ef70b537094fd480e3e0b782bc9d01
Source dataset
uspto-grants-2013_01
Patent number
US08349880B2

Reaction notes

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