Hydrazine → HCID 66858932, compound

Participants

Reaction Steps

Methyl 4-(4-chloro-1H-imidazol-1-yl)-3-methoxyphenylcarbamimidothioate, hydroiodide (500 mg, 1.69 mmol, from preparation A) and 6-chloro-2-(4-chloro-1H-pyrazol-1-yl)hexanoic acid (423 mg, 1.685 mmol, from preparation AK) were coupled and then reacted with hydrazine (0.212 mL, 6.74 mmol) using a procedure analogous to Step A of Example 13 to afford 5-(5-chloro-1-(4-chloro-1H-pyrazol-1-yl)pentyl)-N-(4-(4-chloro-1H-imidazol-1-yl)-3-methoxyphenyl)-1H-1,2,4-triazol-3-amine (956 mg, 1.93 mmol, 100% yield). LC-MS (M+H)+ 497.2. The crude products were used in the subsequent step without purification.

Provenance & Evidence