反应详情

Methyl 4-(4-chloro-1H-imidazol-1-yl)-3-methoxyphenylcarbamimidothioate (1.5 g, 5.05 mmol, from preparation A) and 6-chloro-2-(2-fluorophenyl)hexanoic acid (1.24 g, 5.05 mmol, from preparation AQ) were coupled and then reacted with hydrazine (0.635 mL, 20.2 mmol) using a procedure analogous to Step A of Example 13. The crude product, 5-(5-chloro-1-(2-fluorophenyl)pentyl)-N-(4-(4-chloro-1H-imidazol-1-yl)-3-methoxyphenyl)-1H-1,2,4-triazol-3-amine (2.68 g, 100% yield), was used in the subsequent step without purification. LC-MS (M+H)+ 489.2.