Sodium Iodide → HCID 66858864, compound

Participants

Reaction Steps

A solution of 5-(5-chloro-1-(4-fluorophenyl)-3-methylenepentyl)-N-(3-fluoro-4-(5-methyl-1H-1,2,4-triazol-1-yl)phenyl)-1H-1,2,4-triazol-3-amine (3.33 g, 7.09 mmol), sodium iodide (5.31 g, 35.4 mmol), and diisoproplylethylamine (2.48 mL, 14.2 mmol) in acetone (50 mL) was heated in a sealed vessel at 100° C. for 1 h. The reaction was concentrated in vacuo. The crude product was purified using silica gel column chromatography (50-100% EtOAc/chloroform). The fractions containing product were combined and concentrated to afford N-(3-fluoro-4-(5-methyl-1H-1,2,4-triazol-1-yl)phenyl)-9-(4-fluorophenyl)-7-methylene-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[1,5-a]azepin-2-amine (2.0 g, 52% yield). LC-MS (M+H)+ 434.1.

Provenance & Evidence