Benzene, 1,3-bis(trifluoromethyl)- → HCID 67327055, compound

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Reaction Steps

A 50 mL flask replaced with nitrogen was charged with 500 mg of 1,3-bis[(2,6-diisopropyl)phenyl]imidazolinium tetrafluoroborate and 3 g of methanol. To the resulting mixture, 1.4 mL of a methanol solution of 1 M sodium ethoxide was added dropwise at room temperature over 30 minutes. The resulting mixture was stirred at room temperature for 2 hours and then concentrated. To the residue thus obtained, 5 g of 1,3-bis(trifluoromethyl)benzene was added and then the precipitated solid was removed by filtration. The filtrate was concentrated to obtain 430 mg of 2-methoxy-1,3-bis[(2,6-diisopropyl)phenyl]imidazolidine as a pale yellow crystal, yield: 97%.

Provenance & Evidence