Salicylaldehyde → HCID 136355291, compound

Participants

Reaction Steps

In a 50 ml three-necked flask equipped with a thermometer, a magnetic stirrer and a condenser, 0.14 g of optically enriched (R)-1-benzyl-2,2-dimethoxyethylamine (91% ee, determined by chiral HPLC) (0.71 mmol, 1 mol.eq.) and 0.09 g of salicylaldehyde (0.71 mmol, 1 mol.eq.) are introduced into 1 g of toluene. This medium is left to stir at ambient temperature for 2-3 h. After concentrating, a crude mass of 0.21 g of 2-[(1-benzyl-2,2-dimethoxyethylimino)methyl]phenol is obtained.

Provenance & Evidence