HCID 178522041, compound → HCID 178522038, compound

Participants

Reaction Steps

A mixture of 4-chloro-1-hydroxy-phthalazine-6-carboxylic acid (3-trifluoromethyl-phenyl)-amide (64 mg, 0.174 mmol) (example 25), MeOH (3 mL) and 10% wet Pd/C (catalytic) was evacuated and flushed (3×) with hydrogen. The mixture was stirred under hydrogen for 16 h. The mixture was filtered through celite, rinsed with MeOH and concentrated under vacuum. Chromatography (Hex/EtOAc) was used to obtain 1-hydroxy-phthalazine-6-carboxylic acid (3-trifluoromethyl-phenyl)-amide (20 mg) as a white solid. 1H NMR (400 MHz, CDCl3) δ: 7.35 (d, 1H), 7.45 (t, 1H), 8.03 (s, 1H), 8.08 (d, 1H), 8.19 (s, 1H), 8.30-8.37 (m, 2H), 8.44 (d, 1H), 10.05 (s, 1H), 11.26 (s, 1H) ppm. m/z 334.10.

Provenance & Evidence