HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (3-Piperazin-1-yl-phenyl)-(2-pyrrolidin-1-yl-ethyl)-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-[3-(2-Pyrrolidin-1-yl-ethylamino)-phenyl]-piperazine-1-carboxylic acid tert-butyl ester | HCID 67415909 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | (3-Piperazin-1-yl-phenyl)-(2-pyrrolidin-1-yl-ethyl)-amine | HCID 67416460 | 137.3% |
Reaction Steps
To a solution of 4-[3-(2-pyrrolidin-1-yl-ethylamino)-phenyl]-piperazine-1-carboxylic acid tert-butyl ester (338 mg, 0.90 mmol) in MeOH (10 mL) was added a solution of HCl in IPA (5M, 1.8 mL). The mixture was stirred for 18 h then concentrated to provide the title compound (339 mg, 99%). m/z (M+1) 275.49 (free base).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08349836B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-28ca1b2de41b45d6941c320e28d6dbc0 |
| Source note | uspto-grants-2013_01 |