反应详情

1-(Furan-2-yl)-2-(3-benzyloxyphenyl)ethan-1-one (4 kg, 13.69 mol) was dissolved in MeOH (35 L), and NaBH4 (520 g, 13.75 mol) was slowly added to the solution at 5° C. After the reaction was completed, the solution was quenched with H2O, and the MeOH was evaporated. The residue was extracted with EtOAc and the organic layer was washed with brine, dried over MgSO4, and evaporated to give the 1-(furan-2-yl)-2-(3-benzyloxyphenyl)ethan-1-ol as yellow oil: 3.97 kg (crude yield: 98%)

1. customthe solution was quenched with H2O
2. customthe MeOH was evaporated
3. extractionThe residue was extracted with EtOAc
4. washthe organic layer was washed with brine
5. dry with materialdried over MgSO4
6. customevaporated