C35H42N4O6S → 18-[2-(4-Isopropylthiazole-2-yl)-7-methoxy-8-methylquinolin-4-yloxy]-2,15-dioxo-3,14-diazatricyclo[14.3.0.04,6]nonadec-7-ene-4-carboxylic acid

HRID 1803683Notes

Reaction equation

HRID 1803683 reaction equation
OC1C2C(=C(C)C(OC)=CC=2)N=C(C2SC=C(C(C)C)N=2)C=1.[CH:23]([C:26]1[N:27]=[C:28]([C:31]2[CH:40]=[C:39]([O:41][CH:42]3[CH2:59][CH:58]4[CH:44]([C:45](=[O:65])[N:46]([CH3:64])[CH2:47][CH2:48][CH2:49][CH2:50][CH:51]=[CH:52][CH:53]5[C:55]([C:61]([OH:63])=[O:62])([NH:56][C:57]4=[O:60])[CH2:54]5)[CH2:43]3)[C:38]3[C:33](=[C:34]([CH3:68])[C:35]([O:66][CH3:67])=[CH:36][CH:37]=3)[N:32]=2)[S:29][CH:30]=1)([CH3:25])[CH3:24]>>[CH:23]([C:26]1[N:27]=[C:28]([C:31]2[CH:40]=[C:39]([O:41][CH:42]3[CH2:59][CH:58]4[CH:44]([C:45](=[O:65])[NH:46][CH2:64][CH2:47][CH2:48][CH2:49][CH2:50][CH:51]=[CH:52][CH:53]5[C:55]([C:61]([OH:63])=[O:62])([NH:56][C:57]4=[O:60])[CH2:54]5)[CH2:43]3)[C:38]3[C:33](=[C:34]([CH3:68])[C:35]([O:66][CH3:67])=[CH:36][CH:37]=3)[N:32]=2)[S:29][CH:30]=1)([CH3:25])[CH3:24]

Participants

3

Reactant 2

HCID 66810935C35H42N4O6SHCID 1784876922-(4-Isopropylthiazol-2-YL)-7-methoxy-8-methylquinolin-4-OL

Product 1

HCID 6687214118-[2-(4-Isopropylthiazole-2-yl)-7-methoxy-8-methylquinolin-4-yloxy]-2,15-dioxo-3,14-diazatricyclo[14.3.0.04,6]nonadec-7-ene-4-carboxylic acid

Procedure

The title compound was prepared from intermediate 79 and quinoline 36 following the procedure (Steps D-F) reported for the preparation of 17-[2-(4-isopropylthiazole-2-yl)-7-methoxy-8-methylquinolin-4-yloxy]-13-methyl-2,14-dioxo-3,13-diazatricyclo-[13.3.0.04,6]octadec-7-ene-4-carboxylic acid (46): m/z=647 (M+H)+.

Sources & evidence

ORD record
ord-59dc95f893ab4eed9427a767caada22a
Source dataset
uspto-grants-2013_01
Patent number
US08349869B2

Reaction notes

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