Trifluoroacetic acid → HCID 59552575, compound

Participants

Reaction Steps

To a 10 mL vial with magnetic stir bar was added DCM (0.5 mL) and TFA (0.5 mL). To this, compound 70 was added and let to react for 30 min. After the completion of the reaction, solvents were removed in vacuo, THF was added (0.2 mL) followed by aq. LiOH (0.4 mL) and the reaction stirred for 30 min. After completion of the reaction, THF was removed and the crude residue was purified by HPLC to afford VM3163 (33%) as a colorless solid. LCMS for C27H32N8O10S2, calc'd: 692.17. found: 693.0 (M+H).

Provenance & Evidence