Lithium Hydroxide → HCID 59552439, compound

Participants

Reaction Steps

Compound 141 (5.0 mg, 0.0087 mmol, 1 equiv) in a THF/H2O mixture (1:1, 1 mL) was treated with LiOH (0.4 mg, 0.010 mmol, 1.2 equiv) and irradiated in a Biotage Emrys Optimizer microwave reactor (250 W) at 100° C. for 10 min. After cooling the contents of the tube to room temperature, the solvent was removed and the crude product was purified by HPLC. Yield: 3 mg, 63%.

Provenance & Evidence