反应详情

5-(3,5-Difluoro-phenoxy)-2-nitro-benzonitrile (7.65 g, 27.7 mmol) in dioxane (80 mL) was treated with 10% Pd/C (765 mg) and hydrogenated at 45 psi. After 6 hours the reaction was filtered through a celite funnel and washed with MeOH. The volatiles were evaporated. After purification over silica gel (eluent: hexane:EtOAc 7:3), 4.82 g of title compound were obtained as a pale yellow solid in 71% yield.

1. filtrationAfter 6 hours the reaction was filtered through a celite funnel
2. washwashed with MeOH
3. customThe volatiles were evaporated
4. customAfter purification over silica gel (eluent: hexane:EtOAc 7:3)