HCID 57437983, compound → HCID 86659256, compound

Participants

Reaction Steps

4-(4-Methyl-piperazin-1-yl)-2-[(tetrahydro-pyran-4-yl)-(2,2,2-trifluoro-acetyl)-amino]-benzoyl chloride (10.04 mmol), in dry pyridine (100 mL), under a nitrogen atmosphere, cooled to 4° C., was treated with 5-benzyloxy-1H-indazol-3-ylamine (2 g, 8.37 mmol) in pyridine (35 mL) and stirred for 3 hours. The mixture was concentrated in vacuo. The residue was added to iced water (350 mL) and extracted with EtOAc (400 mL and 2×200 mL). The combined organic layers were dried over anhydrous sodium sulfate. After removal of the volatiles a brown solid was obtained that was taken in Et20 (200 mL), stirred 2 hours at room temperature, filtered and dried at 50° C. under vacuum to afford 4 g of title compound.

Provenance & Evidence