Cyclohexene → HCID 86659259, compound

Participants

Reaction Steps

5-Benzyloxy-3-{4-(4-methyl-piperazin-1-yl)-2-[(tetrahydro-pyran-4-yl)-(2,2,2-trifluoro-acetyl)-amino]-benzoylamino}-indazole-1-carboxylic acid tert-butyl ester (2.3 g, 3.13 mmol) in dioxane (46 mL) was treated with cyclohexene (18 mL) and 10% Pd/C (1.6 g). The mixture was stirred at reflux temperature. After 1.5 hs it was filtered over a celite funnel and washed with dioxane. Evaporation of the solvent left a solid that was washed with Et2O. After drying at 45° C. under vacuum, 1.92 g of title compound in 95% yield were obtained.

Provenance & Evidence