反应详情

温度

40 °C

To a solution of 2-methyl-4-(4-methyl-piperazin-1-yl)-benzoic acid methyl ester (660 mg, 2.66 mmol) in MeOh (4 ml), 2M NaOH (4 ml, 8 mmol) was added. The reaction was heated for 3 hours at 40° C. until HPLC revealed the disappearance of the starting-material. The solvent was removed under reduced pressure and the solution was diluted with water and neutralized to pH 7 with aqueous 25% HCl. The precipitate was filtrated and washed with Et2O to afford the desired final compound as with solid (400 mg, 64%).

1. customThe solvent was removed under reduced pressure
2. additionthe solution was diluted with water and neutralized to pH 7 with aqueous 25% HCl
3. filtrationThe precipitate was filtrated
4. washwashed with Et2O