HRID18039

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID85247

Silane, iodotrimethyl-

C3H9ISi

结构：COc1cc2c(c3c1c(=O)c1cc4ccccc4nc1n3C)[C@@H](OC(C)=O)[C@@H](OC(=O)CNC(=O)OC(C)(C)C)C(C)(C)O2

HCID91322932

未命名化合物

PRODUCTS

生成物

结构：COc1cc2c(c3c1c(=O)c1cc4ccccc4nc1n3C)[C@@H](OC(C)=O)[C@@H](OC(=O)CN)C(C)(C)O2

HCID68585121

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6212

Chloroform

CHCl3

PROCEDURE

实验过程

Add 0.14 μl of iodotrimethylsilane to a solution, at ambient temperature, of 0.1 mmol of the compound of Example 10 in 1 ml of chloroform. The reaction mixture is stirred for 5 min. at ambient temperature and then evaporated to dryness under reduced pressure. Chromatography on silica gel (dichloromethane/methanol:85/15) allows the expected product to be isolated.

WORKUP

后处理

customat ambient temperature
customevaporated to dryness under reduced pressure
customto be isolated

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f38be1e437c248a88931ebf242c1bcb4
来源数据集: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07741325B2
来源说明: uspto-grants-2010_06

反应 SMILES

I[Si](C)(C)C.C(OC([NH:13][CH2:14][C:15]([O:17][C@@H:18]1[C@H:35]([O:36][C:37](=[O:39])[CH3:38])[C:34]2[C:33]3[N:32]([CH3:40])[C:31]4[N:30]=[C:29]5[CH:41]=[CH:42][CH:43]=[CH:44][C:28]5=[CH:27][C:26]=4[C:25](=[O:45])[C:24]=3[C:23]([O:46][CH3:47])=[CH:22][C:21]=2[O:20][C:19]1([CH3:49])[CH3:48])=[O:16])=O)(C)(C)C>C(Cl)(Cl)Cl>[NH2:13][CH2:14][C:15]([O:17][C@@H:18]1[C@H:35]([O:36][C:37](=[O:39])[CH3:38])[C:34]2[C:33]3[N:32]([CH3:40])[C:31]4[N:30]=[C:29]5[CH:41]=[CH:42][CH:43]=[CH:44][C:28]5=[CH:27][C:26]=4[C:25](=[O:45])[C:24]=3[C:23]([O:46][CH3:47])=[CH:22][C:21]=2[O:20][C:19]1([CH3:49])[CH3:48])=[O:16]