1-(2,4-Xylyl)piperazine → HCID 58484529, compound

Participants

Reaction Steps

4-Bromo-2,6-difluorobenzoic acid (5 g) and 4-(4,6-dimethoxy[1.3.5]triazin-2-yl)-4-methylmorpholinium chloride hydrate (DMT-MM) (6.9 g) were dissolved in a mixture of chloroform (50 mL) and methanol (50 mL), 1-(2,4-dimethylphenyl)piperazine (4 g) was added, and the mixture was stirred at room temperature overnight. After evaporation of the solvent, ethyl acetate was added, and insoluble materials were filtered off. The solvent in the filtrate was evaporated to give the title compound (7 g).

Provenance & Evidence