HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(2,4-Xylyl)piperazine → (4-Bromo-2-chloro-5-fluorophenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(2,4-Xylyl)piperazine | HCID 70544 | — |
| Reactant | 4-Bromo-2-chloro-5-fluorobenzoic acid | HCID 2736225 | — |
| Product | (4-Bromo-2-chloro-5-fluorophenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone | HCID 58484863 | 101.2% |
Reaction Steps
By reaction and treatment in the same manner as in Preparation Example 1 and using 4-bromo-2-chloro-5-fluorobenzoic acid (5 g) and 1-(2,4-dimethylphenyl)piperazine (3.8 g), the title compound (8.5 g) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08354401B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-93fa06f9498b42b59d9451374d965bd9 |
| Source note | uspto-grants-2013_01 |