HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → [4-(2,4-Dimethylphenyl)piperazin-1-yl](4-iodophenyl)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 1-(2,4-Xylyl)piperazine | HCID 70544 | — |
| Reactant | 4-Iodobenzoyl chloride | HCID 74373 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | [4-(2,4-Dimethylphenyl)piperazin-1-yl](4-iodophenyl)methanone | HCID 58484733 | 101.4% |
Reaction Steps
To tetrahydrofuran (60 mL) were added 4-iodobenzoyl chloride (5 g), 1-(2,4-dimethylphenyl)piperazine (3.6 g) and 1N aqueous sodium hydroxide solution (20 mL), and the mixture was stirred at room temperature overnight. Ethyl acetate was added for partitioning, the organic layer was washed with saturated brine, and the solvent was evaporated. The title compound (8 g) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08354401B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-cc3d32c8e2ab49d7b226489d80053ed9 |
| Source note | uspto-grants-2013_01 |