1-(2,4-Xylyl)piperazine → HCID 58484693, compound

HRID 1803941Notes

Reaction equation

HRID 1803941 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[CH:4][C:3]=1[CH3:11].[CH3:12][C:13]1[CH:18]=[C:17]([CH3:19])[CH:16]=[CH:15][C:14]=1[N:20]1[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1>>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([N:23]2[CH2:24][CH2:25][N:20]([C:14]3[CH:15]=[CH:16][C:17]([CH3:19])=[CH:18][C:13]=3[CH3:12])[CH2:21][CH2:22]2)=[O:8])=[CH:4][C:3]=1[CH3:11]

Participants

3

Reactant 2

HCID 705441-(2,4-Xylyl)piperazineHCID 821314-Bromo-3-methylbenzoic acid

Product 1

HCID 58484693HCID 58484693, compoundYield 100.5%

Procedure

By reaction and treatment in the same manner as in Preparation Example 1 and using 4-bromo-3-methylbenzoic acid (25 g) and 1-(2,4-dimethylphenyl)piperazine (22 g), the title compound (45 g) was obtained.

Workup

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 1

Sources & evidence

ORD record
ord-f470ef64cc4642218a769e4722583892
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

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