HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → (4-Bromophenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 4-Bromobenzoyl chloride | HCID 68515 | — |
| Reactant | 1-(2,4-Xylyl)piperazine | HCID 70544 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | (4-Bromophenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone | HCID 58484623 | 72.9% |
Reaction Steps
To tetrahydrofuran (120 mL) were added 4-bromobenzoyl chloride (25 g), 1-(2,4-dimethylphenyl)piperazine (22 g) and 1N aqueous sodium hydroxide solution (120 mL), and the mixture was stirred at room temperature for 6 hr. Ethyl acetate was added for partitioning, the organic layer was washed with saturated brine, and the solvent was evaporated. The title compound (31 g) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08354401B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-5b3fdafddb364730ad69bcab19936c72 |
| Source note | uspto-grants-2013_01 |