1-(2,4-Xylyl)piperazine → HCID 58484574, compound

HRID 1803960Notes

Reaction equation

HRID 1803960 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([OH:10])=O)=[N:6][CH:7]=1.[CH3:11][C:12]1[CH:17]=[C:16]([CH3:18])[CH:15]=[CH:14][C:13]=1[N:19]1[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([N:22]2[CH2:23][CH2:24][N:19]([C:13]3[CH:14]=[CH:15][C:16]([CH3:18])=[CH:17][C:12]=3[CH3:11])[CH2:20][CH2:21]2)=[O:10])=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 705441-(2,4-Xylyl)piperazineHCID 6085445-Bromopyridine-2-carboxylic acid

Product 1

HCID 58484574HCID 58484574, compoundYield 101.5%

Procedure

By reaction and treatment in the same manner as in Preparation Example 1 and using 5-bromopyridine-2-carboxylic acid (5 g) and 1-(2,4-dimethylphenyl)piperazine (4.8 g), the title compound (9.4 g) was obtained.

Workup

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 1

Sources & evidence

ORD record
ord-7fa2e5963d4740deae57bcdb56a7c26c
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

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