HRID1803963

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID16213752

未命名化合物

结构：CS(=O)(=O)c1cc(Br)ccc1C(=O)N1CCC(C(=O)c2ccc(Cl)cc2)CC1

HCID67380967

未命名化合物

PRODUCTS

生成物

结构：CS(=O)(=O)c1cc(N2C(=O)OC[C@H]2COC(=O)c2ccccc2)ccc1C(=O)N1CCC(C(=O)c2ccc(Cl)cc2)CC1

HCID54755002

未命名化合物

收率 48.5%

PROCEDURE

实验过程

By reaction and treatment in the same manner as in Preparation Example 1 and using 4-bromo-2-methylsulfonylbenzoic acid (2.8 g) and (4-chlorophenyl)piperidin-4-ylmethanone (2.6 g), (4-bromo-2-methanesulfonylphenyl)[4-(4-chlorobenzoyl)piperidin-1-yl]methanone (4.8 g) was obtained. By reaction and treatment in the same manner as in Preparation Example 12 and using (4-bromo-2-methanesulfonylphenyl)[4-(4-chlorobenzoyl)piperidin-1-yl]methanone (1.5 g) and benzoic acid (R)-2-oxooxazolidin-4-ylmethyl ester (796 mg), the title compound (938 mg) was obtained.

WORKUP

后处理

customBy reaction and treatment in the same manner
customas in Preparation Example 12

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-c9359ff7f8414afd82b5a0102351dfda
来源数据集: uspto-grants-2013_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08354401B2
来源说明: uspto-grants-2013_01

反应 SMILES

Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][CH:13]([C:16](=[O:24])[C:17]3[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=3)[CH2:12][CH2:11]2)=[O:9])=[C:4]([S:25]([CH3:28])(=[O:27])=[O:26])[CH:3]=1.[O:29]=[C:30]1[NH:34][C@H:33]([CH2:35][O:36][C:37](=[O:44])[C:38]2[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=2)[CH2:32][O:31]1>>[Cl:23][C:20]1[CH:21]=[CH:22][C:17]([C:16]([CH:13]2[CH2:14][CH2:15][N:10]([C:8]([C:5]3[CH:6]=[CH:7][C:2]([N:34]4[C@H:33]([CH2:35][O:36][C:37](=[O:44])[C:38]5[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=5)[CH2:32][O:31][C:30]4=[O:29])=[CH:3][C:4]=3[S:25]([CH3:28])(=[O:27])=[O:26])=[O:9])[CH2:11][CH2:12]2)=[O:24])=[CH:18][CH:19]=1